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KMID : 0388220070140030291
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Journal of the Korean Rheumatism Association
2007 Volume.14 No. 3 p.291 ~ p.296
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Reversible Posterior Leukoencephalopathy Syndrome in a Patient withSystemic Lupus Erythematosus Treated with Cyclosporine
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Shin Jae-Dae
Kim Dae-Young
Kim Kyung-Hoon
Nam Eon-Jeong
Kang Young-Mo
Son Ja-Young
Park Jin-Hong
Kim Gun-Woo
Song Eun-Joo
Kim Ji-Min
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Abstract
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Reversible posterior leukoencephalopathy syndrome (RPLS) is characterized clinically by headache, seizure, altered mental status and visual impairment. Neuroimaging shows reversible white matter edema predominantly in the parietal and occipital lobes. RPLS has been associated with a variety of conditions, including hypertensive encephalopathy, renal failure, immunosupressive therapy, and autoimmune diseases such as systemic lupus erythematosus (SLE). We report a young woman of SLE presented with headache, generalized tonic-clonic seizure and altered mental status, after taking azathioprine and cyclosporine. The brain magnetic resonance images showed bilateral hyperintensitiy in the posterior parietal, occipital, temporal lobes and cerebellum on T2-weighted images and fluid attenuated inversion recovery images, whereas diffusion-weighted images showed isointensity in the same distribution. The patient was improved clinically and radiologically one week after the control of hypertension and discontinuation of cyclosporine.
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KEYWORD
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Reversible posterior leukoencephalopathy syndrome, Systemic lupus erythematosus, Cyclosporine
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